Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation.
Identifieur interne : 000617 ( Main/Exploration ); précédent : 000616; suivant : 000618Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation.
Auteurs : Francesco Menzella [Italie] ; Matteo Fontana [Italie] ; Carlo Salvarani [Italie] ; Marco Massari [Italie] ; Patrizia Ruggiero [Italie] ; Chiara Scelfo [Italie] ; Chiara Barbieri [Italie] ; Claudia Castagnetti [Italie] ; Chiara Catellani [Italie] ; Giorgia Gibellini [Italie] ; Francesco Falco [Italie] ; Giulia Ghidoni [Italie] ; Francesco Livrieri [Italie] ; Gloria Montanari [Italie] ; Eleonora Casalini [Italie] ; Roberto Piro [Italie] ; Pamela Mancuso [Italie] ; Luca Ghidorsi [Italie] ; Nicola Facciolongo [Italie]Source :
- Critical care (London, England) [ 1466-609X ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Anticorps monoclonaux humanisés (usage thérapeutique), Betacoronavirus (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (thérapie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (thérapie), Sujet âgé (MeSH), Syndrome de détresse respiratoire de l'adulte (thérapie), Syndrome de détresse respiratoire de l'adulte (virologie), Ventilation non effractive (MeSH), Études cas-témoins (MeSH), Études rétrospectives (MeSH).
- MESH :
- thérapie : Infections à coronavirus, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- usage thérapeutique : Anticorps monoclonaux humanisés.
- virologie : Syndrome de détresse respiratoire de l'adulte.
- Adulte d'âge moyen, Betacoronavirus, Femelle, Humains, Mâle, Pandémies, Sujet âgé, Ventilation non effractive, Études cas-témoins, Études rétrospectives.
English descriptors
- KwdEn :
- Aged (MeSH), Antibodies, Monoclonal, Humanized (therapeutic use), Betacoronavirus (MeSH), Case-Control Studies (MeSH), Coronavirus Infections (therapy), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Noninvasive Ventilation (MeSH), Pandemics (MeSH), Pneumonia, Viral (therapy), Respiratory Distress Syndrome, Adult (therapy), Respiratory Distress Syndrome, Adult (virology), Retrospective Studies (MeSH).
- MESH :
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized.
- therapy : Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- virology : Respiratory Distress Syndrome, Adult.
- Aged, Betacoronavirus, Case-Control Studies, Female, Humans, Male, Middle Aged, Noninvasive Ventilation, Pandemics, Retrospective Studies.
Abstract
BACKGROUND
The severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is extremely variable, ranging from asymptomatic patients to those who develop severe acute respiratory distress syndrome (ARDS). As for now, there are still no really effective therapies for coronavirus disease 2019 (COVID-19). Some evidences suggest that tocilizumab (TCZ) may avoid the progression of severe COVID-19. The aim of this retrospective case-control study was to analyze the efficacy and safety of TCZ in patients with COVID-19 ARDS undergoing noninvasive mechanical ventilation (NIV).
METHODS
Seventy-nine consecutive patients with severe COVID-19 pneumonia and worsening acute respiratory failure (ARF) were admitted to the Pulmonology Unit of Azienda USL of Reggio Emilia-IRCCS. All patients were inflamed (elevated CRP and IL-6 levels) and received NIV at admission according to the presence of a pO
RESULTS
Out of 79 patients, 41 were treated with TCZ. Twenty-eight patients received intravenous (IV) TCZ and 13 patients received subcutaneous (SC) TCZ. In-hospital overall mortality rate was 38% (30/79 patients). The probabilities of dying and being intubated during the follow-up using Kaplan-Meier method were significantly lower in total patients treated with TCZ compared to those of patients not treated with TCZ (log-rank p value = 0.006 and 0.036, respectively). However, using Cox multivariate analyses adjusted for age and Charlson comorbidity index only the association with the reduced risk of being intubated or dying maintained the significance (HR 0.44, 95%CI 0.22-0.89, p = 0.022). Two patients treated with TCZ developed cavitating lung lesions during the follow-up.
CONCLUSIONS
This study shows that TCZ treatment may be effective in COVID-19 patients with severe respiratory impairment receiving NIV. More data on safety are required. Randomized controlled trials are needed to confirm these results.
DOI: 10.1186/s13054-020-03306-6
PubMed: 32993751
PubMed Central: PMC7523258
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation.</title><author><name sortKey="Menzella, Francesco" sort="Menzella, Francesco" uniqKey="Menzella F" first="Francesco" last="Menzella">Francesco Menzella</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy. francesco.menzella@ausl.re.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Fontana, Matteo" sort="Fontana, Matteo" uniqKey="Fontana M" first="Matteo" last="Fontana">Matteo Fontana</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Salvarani, Carlo" sort="Salvarani, Carlo" uniqKey="Salvarani C" first="Carlo" last="Salvarani">Carlo Salvarani</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Rheumatology, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Massari, Marco" sort="Massari, Marco" uniqKey="Massari M" first="Marco" last="Massari">Marco Massari</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Disease Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Infectious Disease Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Ruggiero, Patrizia" sort="Ruggiero, Patrizia" uniqKey="Ruggiero P" first="Patrizia" last="Ruggiero">Patrizia Ruggiero</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Scelfo, Chiara" sort="Scelfo, Chiara" uniqKey="Scelfo C" first="Chiara" last="Scelfo">Chiara Scelfo</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Barbieri, Chiara" sort="Barbieri, Chiara" uniqKey="Barbieri C" first="Chiara" last="Barbieri">Chiara Barbieri</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Castagnetti, Claudia" sort="Castagnetti, Claudia" uniqKey="Castagnetti C" first="Claudia" last="Castagnetti">Claudia Castagnetti</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Catellani, Chiara" sort="Catellani, Chiara" uniqKey="Catellani C" first="Chiara" last="Catellani">Chiara Catellani</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Gibellini, Giorgia" sort="Gibellini, Giorgia" uniqKey="Gibellini G" first="Giorgia" last="Gibellini">Giorgia Gibellini</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Falco, Francesco" sort="Falco, Francesco" uniqKey="Falco F" first="Francesco" last="Falco">Francesco Falco</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Ghidoni, Giulia" sort="Ghidoni, Giulia" uniqKey="Ghidoni G" first="Giulia" last="Ghidoni">Giulia Ghidoni</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Livrieri, Francesco" sort="Livrieri, Francesco" uniqKey="Livrieri F" first="Francesco" last="Livrieri">Francesco Livrieri</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Montanari, Gloria" sort="Montanari, Gloria" uniqKey="Montanari G" first="Gloria" last="Montanari">Gloria Montanari</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Casalini, Eleonora" sort="Casalini, Eleonora" uniqKey="Casalini E" first="Eleonora" last="Casalini">Eleonora Casalini</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Piro, Roberto" sort="Piro, Roberto" uniqKey="Piro R" first="Roberto" last="Piro">Roberto Piro</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Mancuso, Pamela" sort="Mancuso, Pamela" uniqKey="Mancuso P" first="Pamela" last="Mancuso">Pamela Mancuso</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Ghidorsi, Luca" sort="Ghidorsi, Luca" uniqKey="Ghidorsi L" first="Luca" last="Ghidorsi">Luca Ghidorsi</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Facciolongo, Nicola" sort="Facciolongo, Nicola" uniqKey="Facciolongo N" first="Nicola" last="Facciolongo">Nicola Facciolongo</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32993751</idno><idno type="pmid">32993751</idno><idno type="doi">10.1186/s13054-020-03306-6</idno><idno type="pmc">PMC7523258</idno><idno type="wicri:Area/Main/Corpus">000051</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000051</idno><idno type="wicri:Area/Main/Curation">000051</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000051</idno><idno type="wicri:Area/Main/Exploration">000051</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation.</title><author><name sortKey="Menzella, Francesco" sort="Menzella, Francesco" uniqKey="Menzella F" first="Francesco" last="Menzella">Francesco Menzella</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy. francesco.menzella@ausl.re.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Fontana, Matteo" sort="Fontana, Matteo" uniqKey="Fontana M" first="Matteo" last="Fontana">Matteo Fontana</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Salvarani, Carlo" sort="Salvarani, Carlo" uniqKey="Salvarani C" first="Carlo" last="Salvarani">Carlo Salvarani</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Rheumatology, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Massari, Marco" sort="Massari, Marco" uniqKey="Massari M" first="Marco" last="Massari">Marco Massari</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Disease Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Infectious Disease Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Ruggiero, Patrizia" sort="Ruggiero, Patrizia" uniqKey="Ruggiero P" first="Patrizia" last="Ruggiero">Patrizia Ruggiero</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Scelfo, Chiara" sort="Scelfo, Chiara" uniqKey="Scelfo C" first="Chiara" last="Scelfo">Chiara Scelfo</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Barbieri, Chiara" sort="Barbieri, Chiara" uniqKey="Barbieri C" first="Chiara" last="Barbieri">Chiara Barbieri</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Castagnetti, Claudia" sort="Castagnetti, Claudia" uniqKey="Castagnetti C" first="Claudia" last="Castagnetti">Claudia Castagnetti</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Catellani, Chiara" sort="Catellani, Chiara" uniqKey="Catellani C" first="Chiara" last="Catellani">Chiara Catellani</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Gibellini, Giorgia" sort="Gibellini, Giorgia" uniqKey="Gibellini G" first="Giorgia" last="Gibellini">Giorgia Gibellini</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Falco, Francesco" sort="Falco, Francesco" uniqKey="Falco F" first="Francesco" last="Falco">Francesco Falco</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Ghidoni, Giulia" sort="Ghidoni, Giulia" uniqKey="Ghidoni G" first="Giulia" last="Ghidoni">Giulia Ghidoni</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Livrieri, Francesco" sort="Livrieri, Francesco" uniqKey="Livrieri F" first="Francesco" last="Livrieri">Francesco Livrieri</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Montanari, Gloria" sort="Montanari, Gloria" uniqKey="Montanari G" first="Gloria" last="Montanari">Gloria Montanari</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Casalini, Eleonora" sort="Casalini, Eleonora" uniqKey="Casalini E" first="Eleonora" last="Casalini">Eleonora Casalini</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Piro, Roberto" sort="Piro, Roberto" uniqKey="Piro R" first="Roberto" last="Piro">Roberto Piro</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Mancuso, Pamela" sort="Mancuso, Pamela" uniqKey="Mancuso P" first="Pamela" last="Mancuso">Pamela Mancuso</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Ghidorsi, Luca" sort="Ghidorsi, Luca" uniqKey="Ghidorsi L" first="Luca" last="Ghidorsi">Luca Ghidorsi</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author><author><name sortKey="Facciolongo, Nicola" sort="Facciolongo, Nicola" uniqKey="Facciolongo N" first="Nicola" last="Facciolongo">Nicola Facciolongo</name><affiliation wicri:level="1"><nlm:affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia</wicri:regionArea><wicri:noRegion>Reggio Emilia</wicri:noRegion></affiliation></author></analytic><series><title level="j">Critical care (London, England)</title><idno type="eISSN">1466-609X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Betacoronavirus (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Coronavirus Infections (therapy)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Noninvasive Ventilation (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (therapy)</term><term>Respiratory Distress Syndrome, Adult (therapy)</term><term>Respiratory Distress Syndrome, Adult (virology)</term><term>Retrospective Studies (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Anticorps monoclonaux humanisés (usage thérapeutique)</term><term>Betacoronavirus (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (thérapie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (thérapie)</term><term>Sujet âgé (MeSH)</term><term>Syndrome de détresse respiratoire de l'adulte (thérapie)</term><term>Syndrome de détresse respiratoire de l'adulte (virologie)</term><term>Ventilation non effractive (MeSH)</term><term>Études cas-témoins (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Betacoronavirus</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Noninvasive Ventilation</term><term>Pandemics</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term><term>Sujet âgé</term><term>Ventilation non effractive</term><term>Études cas-témoins</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is extremely variable, ranging from asymptomatic patients to those who develop severe acute respiratory distress syndrome (ARDS). As for now, there are still no really effective therapies for coronavirus disease 2019 (COVID-19). Some evidences suggest that tocilizumab (TCZ) may avoid the progression of severe COVID-19. The aim of this retrospective case-control study was to analyze the efficacy and safety of TCZ in patients with COVID-19 ARDS undergoing noninvasive mechanical ventilation (NIV).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Seventy-nine consecutive patients with severe COVID-19 pneumonia and worsening acute respiratory failure (ARF) were admitted to the Pulmonology Unit of Azienda USL of Reggio Emilia-IRCCS. All patients were inflamed (elevated CRP and IL-6 levels) and received NIV at admission according to the presence of a pO</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Out of 79 patients, 41 were treated with TCZ. Twenty-eight patients received intravenous (IV) TCZ and 13 patients received subcutaneous (SC) TCZ. In-hospital overall mortality rate was 38% (30/79 patients). The probabilities of dying and being intubated during the follow-up using Kaplan-Meier method were significantly lower in total patients treated with TCZ compared to those of patients not treated with TCZ (log-rank p value = 0.006 and 0.036, respectively). However, using Cox multivariate analyses adjusted for age and Charlson comorbidity index only the association with the reduced risk of being intubated or dying maintained the significance (HR 0.44, 95%CI 0.22-0.89, p = 0.022). Two patients treated with TCZ developed cavitating lung lesions during the follow-up.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>This study shows that TCZ treatment may be effective in COVID-19 patients with severe respiratory impairment receiving NIV. More data on safety are required. Randomized controlled trials are needed to confirm these results.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32993751</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>08</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1466-609X</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>09</Month><Day>29</Day></PubDate></JournalIssue><Title>Critical care (London, England)</Title><ISOAbbreviation>Crit Care</ISOAbbreviation></Journal><ArticleTitle>Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation.</ArticleTitle><Pagination><MedlinePgn>589</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13054-020-03306-6</ELocationID><Abstract><AbstractText Label="BACKGROUND">The severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is extremely variable, ranging from asymptomatic patients to those who develop severe acute respiratory distress syndrome (ARDS). As for now, there are still no really effective therapies for coronavirus disease 2019 (COVID-19). Some evidences suggest that tocilizumab (TCZ) may avoid the progression of severe COVID-19. The aim of this retrospective case-control study was to analyze the efficacy and safety of TCZ in patients with COVID-19 ARDS undergoing noninvasive mechanical ventilation (NIV).</AbstractText><AbstractText Label="METHODS">Seventy-nine consecutive patients with severe COVID-19 pneumonia and worsening acute respiratory failure (ARF) were admitted to the Pulmonology Unit of Azienda USL of Reggio Emilia-IRCCS. All patients were inflamed (elevated CRP and IL-6 levels) and received NIV at admission according to the presence of a pO<sub>2</sub>/FiO<sub>2</sub> ratio ≤ 200 mmHg. The possibility of being treated with TCZ depended on the drug availability. The primary outcome was the in-hospital mortality rate. A secondary composite outcome of worsening was represented by the patients who died in the pulmonology unit or were intubated.</AbstractText><AbstractText Label="RESULTS">Out of 79 patients, 41 were treated with TCZ. Twenty-eight patients received intravenous (IV) TCZ and 13 patients received subcutaneous (SC) TCZ. In-hospital overall mortality rate was 38% (30/79 patients). The probabilities of dying and being intubated during the follow-up using Kaplan-Meier method were significantly lower in total patients treated with TCZ compared to those of patients not treated with TCZ (log-rank p value = 0.006 and 0.036, respectively). However, using Cox multivariate analyses adjusted for age and Charlson comorbidity index only the association with the reduced risk of being intubated or dying maintained the significance (HR 0.44, 95%CI 0.22-0.89, p = 0.022). Two patients treated with TCZ developed cavitating lung lesions during the follow-up.</AbstractText><AbstractText Label="CONCLUSIONS">This study shows that TCZ treatment may be effective in COVID-19 patients with severe respiratory impairment receiving NIV. More data on safety are required. Randomized controlled trials are needed to confirm these results.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Menzella</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0003-3950-5789</Identifier><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy. francesco.menzella@ausl.re.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fontana</LastName><ForeName>Matteo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salvarani</LastName><ForeName>Carlo</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Modena and Reggio Emilia, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Massari</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Infectious Disease Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruggiero</LastName><ForeName>Patrizia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scelfo</LastName><ForeName>Chiara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barbieri</LastName><ForeName>Chiara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castagnetti</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Catellani</LastName><ForeName>Chiara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gibellini</LastName><ForeName>Giorgia</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falco</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghidoni</LastName><ForeName>Giulia</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Livrieri</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montanari</LastName><ForeName>Gloria</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casalini</LastName><ForeName>Eleonora</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piro</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mancuso</LastName><ForeName>Pamela</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Epidemiology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghidorsi</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Facciolongo</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Crit Care</MedlineTA><NlmUniqueID>9801902</NlmUniqueID><ISSNLinking>1364-8535</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D061067">Antibodies, Monoclonal, Humanized</NameOfSubstance></Chemical><Chemical><RegistryNumber>I031V2H011</RegistryNumber><NameOfSubstance UI="C502936">tocilizumab</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061067" MajorTopicYN="N">Antibodies, Monoclonal, Humanized</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D063087" MajorTopicYN="Y">Noninvasive Ventilation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Acute respiratory distress syndrome</Keyword><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Noninvasive ventilation</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">Tocilizumab</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>30</Day><Hour>5</Hour><Minute>47</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32993751</ArticleId><ArticleId IdType="doi">10.1186/s13054-020-03306-6</ArticleId><ArticleId IdType="pii">10.1186/s13054-020-03306-6</ArticleId><ArticleId IdType="pmc">PMC7523258</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Autoimmun Rev. 2020 Jul;19(7):102568</Citation><ArticleIdList><ArticleId IdType="pubmed">32376398</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Jul 11;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32651997</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2016 May 05;6:25359</Citation><ArticleIdList><ArticleId IdType="pubmed">27146253</ArticleId></ArticleIdList></Reference><Reference><Citation>Chest. 2020 Jun 15;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32553536</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Rheumatol. 2020 May-Jun;38(3):529-532</Citation><ArticleIdList><ArticleId IdType="pubmed">32359035</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Opin Biol Ther. 2020 Jul;20(7):717-723</Citation><ArticleIdList><ArticleId IdType="pubmed">32406282</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Rheumatol. 2020 Aug;2(8):e474-e484</Citation><ArticleIdList><ArticleId IdType="pubmed">32835257</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 Apr 28;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32343429</ArticleId></ArticleIdList></Reference><Reference><Citation>J Allergy Clin Immunol. 2020 Jul;146(1):128-136.e4</Citation><ArticleIdList><ArticleId IdType="pubmed">32425269</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975</Citation><ArticleIdList><ArticleId IdType="pubmed">32350134</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation><ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Virol. 2020 Jul;128:104415</Citation><ArticleIdList><ArticleId IdType="pubmed">32403011</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Clin Pharmacol Ther. 2013 Jun;51(6):443-55</Citation><ArticleIdList><ArticleId IdType="pubmed">23547848</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Pharmacokinet. 2013 Feb;52(2):83-124</Citation><ArticleIdList><ArticleId IdType="pubmed">23299465</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Resusc. 2020 Apr 23;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32353223</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2020 May 6;24(1):198</Citation><ArticleIdList><ArticleId IdType="pubmed">32375845</ArticleId></ArticleIdList></Reference><Reference><Citation>Respirology. 2006 Nov;11(6):715-22</Citation><ArticleIdList><ArticleId IdType="pubmed">17052299</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2020 Sep;56(3):106103</Citation><ArticleIdList><ArticleId IdType="pubmed">32712333</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 Jun 4;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32497297</ArticleId></ArticleIdList></Reference><Reference><Citation>Cytokine Growth Factor Rev. 2020 Jun;53:38-42</Citation><ArticleIdList><ArticleId IdType="pubmed">32360420</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2020 May 22;369:m1966</Citation><ArticleIdList><ArticleId IdType="pubmed">32444366</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Respir J. 2017 Aug 31;50(2):</Citation><ArticleIdList><ArticleId IdType="pubmed">28860265</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Rheum Dis. 2020 Sep;79(9):1143-1151</Citation><ArticleIdList><ArticleId IdType="pubmed">32719045</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Intern Med. 2020 Jun;76:43-49</Citation><ArticleIdList><ArticleId IdType="pubmed">32482597</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Jul 17;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32678530</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Menzella, Francesco" sort="Menzella, Francesco" uniqKey="Menzella F" first="Francesco" last="Menzella">Francesco Menzella</name></noRegion><name sortKey="Barbieri, Chiara" sort="Barbieri, Chiara" uniqKey="Barbieri C" first="Chiara" last="Barbieri">Chiara Barbieri</name><name sortKey="Casalini, Eleonora" sort="Casalini, Eleonora" uniqKey="Casalini E" first="Eleonora" last="Casalini">Eleonora Casalini</name><name sortKey="Castagnetti, Claudia" sort="Castagnetti, Claudia" uniqKey="Castagnetti C" first="Claudia" last="Castagnetti">Claudia Castagnetti</name><name sortKey="Catellani, Chiara" sort="Catellani, Chiara" uniqKey="Catellani C" first="Chiara" last="Catellani">Chiara Catellani</name><name sortKey="Facciolongo, Nicola" sort="Facciolongo, Nicola" uniqKey="Facciolongo N" first="Nicola" last="Facciolongo">Nicola Facciolongo</name><name sortKey="Falco, Francesco" sort="Falco, Francesco" uniqKey="Falco F" first="Francesco" last="Falco">Francesco Falco</name><name sortKey="Fontana, Matteo" sort="Fontana, Matteo" uniqKey="Fontana M" first="Matteo" last="Fontana">Matteo Fontana</name><name sortKey="Ghidoni, Giulia" sort="Ghidoni, Giulia" uniqKey="Ghidoni G" first="Giulia" last="Ghidoni">Giulia Ghidoni</name><name sortKey="Ghidorsi, Luca" sort="Ghidorsi, Luca" uniqKey="Ghidorsi L" first="Luca" last="Ghidorsi">Luca Ghidorsi</name><name sortKey="Gibellini, Giorgia" sort="Gibellini, Giorgia" uniqKey="Gibellini G" first="Giorgia" last="Gibellini">Giorgia Gibellini</name><name sortKey="Livrieri, Francesco" sort="Livrieri, Francesco" uniqKey="Livrieri F" first="Francesco" last="Livrieri">Francesco Livrieri</name><name sortKey="Mancuso, Pamela" sort="Mancuso, Pamela" uniqKey="Mancuso P" first="Pamela" last="Mancuso">Pamela Mancuso</name><name sortKey="Massari, Marco" sort="Massari, Marco" uniqKey="Massari M" first="Marco" last="Massari">Marco Massari</name><name sortKey="Montanari, Gloria" sort="Montanari, Gloria" uniqKey="Montanari G" first="Gloria" last="Montanari">Gloria Montanari</name><name sortKey="Piro, Roberto" sort="Piro, Roberto" uniqKey="Piro R" first="Roberto" last="Piro">Roberto Piro</name><name sortKey="Ruggiero, Patrizia" sort="Ruggiero, Patrizia" uniqKey="Ruggiero P" first="Patrizia" last="Ruggiero">Patrizia Ruggiero</name><name sortKey="Salvarani, Carlo" sort="Salvarani, Carlo" uniqKey="Salvarani C" first="Carlo" last="Salvarani">Carlo Salvarani</name><name sortKey="Salvarani, Carlo" sort="Salvarani, Carlo" uniqKey="Salvarani C" first="Carlo" last="Salvarani">Carlo Salvarani</name><name sortKey="Scelfo, Chiara" sort="Scelfo, Chiara" uniqKey="Scelfo C" first="Chiara" last="Scelfo">Chiara Scelfo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000617 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000617 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidSeniorV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32993751
|texte= Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32993751" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidSeniorV1
| This area was generated with Dilib version V0.6.37. |  |